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Keep this study
Lead
Medical University of Lodz
With
Shire
Recent experimental studies have shown that a non-calcium based phosphate binder sevelamer hydrochloride can increase intestinal calcium absorption in contrast to lanthanum carbonate. It is unknown whether such the difference may have an effect on bone metabolism and/or modify the development of vascular calcification in patients with chronic kidney disease. The aim of the study was to compare the effect of a single dose of 1000 mg of lanthanum carbonate with 2,4 mg of sevelamer hydrochloride on serum and urine calcium following an oral load of 5 g of calcium carbonate given with a meal with standardized phosphate content.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
adult patient
with eGFR ≤45 ml/min
You may not be if
hypercalcemia (\>ULN),
serum phosphate \>1.2 times normal value
calcium-phosphate disturbances not associated with CKD, e.g. Paget disease, osteoporosis, any bone fracture within 6 months before study, multiple myeloma or any neoplastic disease, liver or biliary tract disease, primary hyperparathyroidism
Clareo Health | Different Effects of Non-calcium Phosphate Binders on Serum Calcium
