Finding studies
Finding studies
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Lead
Daniela A. Bota
With
Primary Objective: The primary objective will be to determine the efficacy of NOVOTTF-200A in recurrent anaplastic astrocytoma patients (6-month progression-free survival) Secondary Objectives: * To evaluate the safety of NOVOTTF-200A in the subject population. * To evaluate efficacy of NOVOTTF-200A in the subject population. * To see if the presence of ATRX, TERT promoter, IDH1 mutations and/or MGMT promoter methylation, confers a better response to NOVOTTF-200A. * To determine if the treatment significantly modifies the patient's quality of life. Sponsor will use the Functional Assessment of Cancer Therapy (FACT) questionnaires: * FACT-Brain (FACT-Br) * FACT-Cognitive Function (FACT-Cog) Exploratory Objectives: * To determine if the presence of proneural or mesenchymal phenotype (Cytoscan analysis) confers a better response to NovoTTF. * To determine if the in vitro sensitivity of the glioma cells derived from patient specimens before and after the NOVOTTF-200A treatment correlates with the patient's response to treatment.
Age
22–any
Sex
ALL
Healthy volunteers
Not accepted
