Comprehensive Lifestyle Change To Prevent Breast Cancer

PRIMARY OBJECTIVES: I. Assess the feasibility of a randomized controlled trial involving a mobile, standardized, comprehensive integrative oncology (IO) prevention program. SECONDARY OBJECTIVES: I. Compare group differences over time in biological pathways including: immune function, gut microbiome, endocrine function, insulin and glucose metabolism, inflammation, other cancer-related pathways (from peripheral blood), antioxidant capacity, and nutrient levels. II. Determine whether the IO group has improved patient reported outcomes over time including: quality of life, sleep disturbances, aspects of mental health, and psychosocial measures including: mindfulness, social support, and measures of positive growth. III. Compare group differences over time in dietary patterns, fitness levels, percent body fat, and anthropometrics. OUTLINE: Patients are randomized into 1 of 2 groups. GROUP I: Patients attend IO prevention program consisting of 1-2 physical activity, nutrition and diet, and mind-body practice sessions over 60 minutes weekly for 12 weeks. Patients also attend a behavioral counseling session once weekly for up to 26 weeks. Patients complete exercises over 30-60 minutes 3-5 times weekly for 12 weeks. GROUP II: Patients receive no intervention. After 26 weeks, patients may crossover to Group I. After completion of study, patients are followed up at 26 weeks and 1 year.