A Study to Investigate the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of TAK-079 Administered Subcutaneously as a Single Agent in Participants With Relapsed/Refractory (r/r) Multiple Myeloma (MM)

1. Eastern Cooperative Oncology Group (ECOG) performance status of \<=2.

2. Has received previous myeloma-specific therapy.

3. In the Combination Cohort (TAK-079-PomDex) only must be able to take concurrent prophylactic anticoagulation per standard clinical practice as directed by the investigator and the Pomalyst product information.

4. Documentation of RRMM as defined by the International Myeloma Working Group (IMWG) criteria.

5. For Participants with MM, measurable disease defined as one of the following:

* Serum M-protein \>=0.5 g/dL (\>=5 gram per liter \[g/L\]).

* Urine M-protein \>=200 mg/24 hours.

* In participants without measurable M-protein in serum protein electrophoresis (SPEP) or urine protein electrophoresis (UPEP), a serum FLC assay result with involved FLC level \>=10 mg/dL (\>=100 milligram per liter \[mg/L\]), provided serum FLC ratio is abnormal.

6. Prior therapy should meet all the following criteria:

Participants in the dose Escalation Cohort (escalation phase) and participants in the dose Confirmation Cohort;

* Should be previously treated with at least a proteasome inhibitor (PI), an immunomodulatory drug (IMiD), and a steroid. Note: Participants who have had a previous autologous stem cell transplant will have additionally been exposed to an alkylating agent; however, participant who have not had a previous autologous stem cell transplant may not have been exposed to an alkylating agent per standard practice.

* Should be refractory or intolerant to at least 1 PI and at least 1 IMiD.

* Should either have received \>= 3 prior lines of therapy or should have received at least 2 prior lines of therapy if one of those lines included a combination of PI and IMiD.

* In phase 1, previous exposure to an anti-CD38 agent, as a single agent or in combination, is allowed but is not required. (Participants in the dose Escalation Cohort).

* In phase 1 dose Confirmation Cohort, cohorts of participants that are refractory at any time to at least 1 anti-CD38 agent or who are anti-CD38 naïve will be enrolled.

Participants in the Combination Cohort (TAK-079 added to PomDex cohort only):

* Have undergone prior therapy with \>=2 prior anti-myeloma therapies (line of therapy defined below).

* Has either relapsed or relapsed and refractory disease. Should have progressed on or within 60 days of completing the last anti-myeloma therapy (refractory defined below).

7. In the phase 2a portion of the study, up to 2 cohorts of participants with RRMM may be enrolled: 1 that is refractory to at least 1 anti-CD38 monoclonal antibody (mAb) therapy at any time during treatment and 1 that is naïve to daratumumab.

Note:

o Refractory is defined as at least a 25% increase in M-protein (response of stable disease during prior therapy) or PD during treatment or within 60 days after last dose of prior therapy.

What this study is about