Finding studies
Finding studies
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Lead
University of California, San Diego
With
The primary objective of the study is to prospectively assess utility of axitinib in facilitation of partial nephrectomy where partial nephrectomy was not thought to be safe/possible in the setting of imperative indication for complex renal masses in renal cell cancer. Secondary objectives: To determine the safety, tumor diameter (per RECIST v1.1) volume change, surgical morbidity and renal functional outcomes following neoadjuvant axitinib for RCC. Anatomical/morphometric: 1. tumor diameter/volume change, 2. conversion of hilar to non-hilar tumors, 3. reduction in RENAL morphometric score. Functional Considerations: 1. Requirement of acute dialysis 2. Change in Glomerular Filtration Rate (GFR) 3. Whether or not GFR crosses 30 threshold, or decline by GFR to \>50% of baseline. Safety indices: 1. Incidence of Clavien \>3 complications 2. Avoidance of need for multiple blood transfusions
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted