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Estrogen and Diabetes | Clinical Trials | Clareo Health

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COMPLETEDNANCT03436992

Estrogen and Diabetes

Diabetes has recently been referred to as "the epidemic of the 21st century". The reason why women with type 1 diabetes have a 2-3 fold greater risk of cardiovascular disease (CVD) compared to men wit...

Lead sponsor: Augusta University•2 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Augusta University

Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Age

18 - 40 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Both men and premenopausal
•Normal menstrual cycle interval of 25-35 days for at least 3 previous cycles
•All races
•Clinical diagnosis of insulin-dependent type 1 diabetes (patients only)

Exclusion Criteria

•Clinical diagnosis of hepatic, cardiovascular, or renal disease
•Uncontrolled Diabetes (HbA1c\>9%)
•Diabetic complications (i.e. macrovascular, microvascular, or autonomic)
•Proteinuria
•Uncontrolled Hypertension (\>140/90 mmHg on therapy)
•Hormonal use of birth control (past 3 months)
•Pregnancy
•Oligomenorrhea
•Direct vasoactive medications (i.e. nitrates)
•Anti-estrogens (i.e. SERMs)
•Plycystic ovarian syndrome (defined by NIH guidelines-hyperandrogenic anovulation)
•Undetectable Anti-Mullerian Hormone (AMH) following screening

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 17, 2025Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment143

Start dateApr 2018

Last updatedFeb 17, 2025

Condition

Diabetes Mellitus, Type 1

Locations shown

Augusta University

Augusta, Georgia

Georgia Prevention Institute

Augusta, Georgia

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 17, 2025Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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