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Keep this study
Lead
British Columbia Cancer Agency
With
BC Cancer Foundation
Men suitable for prostate brachytherapy as monotherapy will undergo multiparametric Magnetic Resonance Imaging for staging and identification of a dominant lesion and will be randomly selected for either a single low dose rate permanent seed implant or 2 fractions of high dose rate brachytherapy. Using image registration techniques, dominant lesions will be biopsied under anesthesia at the start of the brachytherapy procedure. Biopsies will reviewed for tumor Gleason score and sent for Cell Cycle Progression testing (Prolaris). Patients receiving high dose rate brachytherapy will also have biopsies between the 2 fractions to assess tumor changes induced from the first fraction. Post implant quality assurance will determine the dose to the dominant lesions and compare these between the 2 types of brachytherapy. Post implant symptoms will be tracked for severity and time course.
Age
40–80
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Favorable risk and low-tier intermediate-risk prostate cancer with estimated life expectancy of at least 10 years.
Clinical stage T1c-T2b, PSA \< 20, Gleason \< 8
ECOG 0-1
Low tier intermediate-risk prostate cancer is defined by a single NCCN intermediate risk factor
Extensive favorable-risk disease is defined as:
* clinical stage T1c-T2a
* PSA \< 10
* Gleason 6
* ≥ 50% of biopsy cores containing cancer
* PSA density \> 0.2 ng/cc
Selected intermediate risk patients not defined above
* \- T1c/T2a
* \- PSA \< 10
* -Gleason 4+3
* PSA \> 10 and Gleason 3+4
* PSA 10-15 ng/ml and Gleason 4+3
* -\< 33% of cores involved
* -Max tumor length in any core 10 mm
No androgen deprivation therapy (ADT)
Prostate volume by TRUS ≤ 60 cc.
You may not be if
Signed study specific informed consent.
Prior radical surgery for carcinoma of the prostate,
Prior pelvic radiation
Prior chemotherapy for prostate cancer,
Prior TURP or cryosurgery of the prostate
Claustrophobic or unable to undergo MRI
Clareo Health | LDR vs. HDR Brachytherapy for Prostate Cancer
