11C-Trimethoprim PET/CT Imaging to Evaluate Biodistribution and Kinetics in Human Subjects

Exclusion Criteria

• •1. Antibiotic therapy with trimethoprim within 48h of the baseline PET/CT scan.
• •2. Inability to tolerate imaging procedures in the opinion of an investigator or treating physician
• •3. Serious or unstable medical or psychological comorbidities that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study.
• •4. Females who are pregnant or breast feeding at the time of screening will not be eligible for this study; a urine pregnancy test will be performed in women of child-bearing potential at screening.