Circulating microRNAs as Biomarkers of RESPIratory Dysfunction in Patients With Refractory epilePSY

Exclusion Criteria

• •For the patients :
• •Ongoing major depressive episode as defined by a score ≥ 15 at the French version of the NDDI-E scale\*
• •Current panic disorder as defined by a score ≥ 7 at the French version of the GAD-7 scale\*
• •Ongoing treatment with selective serotonin reuptake inhibitor
• •Patient who benefit from a protective measure
• •For the healthy volunteers :
• •Presence of the symptoms of anxiety and/or depression as defined by a score ≥ 11 at the French version of the Hospital Anxiety and Depression Scale (HADS)
• •Ongoing treatment with selective serotonin reuptake inhibitor
• •Subjects with these psychiatric comorbidities and/or treatment will be excluded in order to limit risk that the relation previously reported between miR-135a, miR-16, miR-1202 and depression and/or panic disorder and/or response to selective serotonin