Effects of Salvinorin A on Brain Function

Exclusion Criteria

• •Women who are pregnant (as indicated by a positive urine pregnancy test assessed at intake and before each drug session) or nursing; women who are of child-bearing potential and sexually active who are not practicing an effective means of birth control
• •Cardiovascular conditions: coronary artery disease, stroke, angina, uncontrolled hypertension, or Transient Ischemic Attack (TIA) in the past year
• •Seizure disorder or epilepsy with history of seizures
• •Insulin-dependent diabetes; if taking oral hypoglycemic agent, then no history of hypoglycemia
• •Currently taking psychoactive prescription medication on a regular (e.g., daily) basis
• •More than 25% outside the upper or lower range of ideal body weight
• •Current or past history of meeting Diagnostic and Statistical Manual (DSM)-V criteria for schizophrenia, psychotic disorder (unless substance-induced or due to a medical condition), dissociative disorder, bipolar I or II disorder, an eating disorder
• •Current or past history of substance-induced psychosis.
• •Current or past history within the last 2 years of meeting DSM-5 criteria for moderate or severe alcohol or substance use disorder (excluding caffeine)
• •Daily or more frequent tobacco or nicotine use
• •Current severe obsessive-compulsive disorder, dysthymic disorder, or panic disorder.
• •Current, severe, major depression
• •Have a first or second degree relative with schizophrenia, psychotic disorder (unless substance induced or due to a medical condition), or bipolar I or II disorder
• •Has a psychiatric condition judged to be incompatible with establishment of rapport or safe exposure to salvinorin A
• •Head trauma, traumatic brain injury, or concussion with loss of consciousness for \>2 minutes
• •Claustrophobia incompatible with MRI scanning
• •Medical device incompatible with MRI scanning (e.g. cardiac pacemaker, implanted cardiac defibrillator, aneurysm brain clip, inner ear implant)
• •Prior history as a metal worker and/or certain metallic objects in the body -- must complete MRI screening form and be approved by MRI technologist before each scan
• •Left-handedness (assessed by the Edinburgh Handedness Inventory)