Patient with mucosal melanoma

Patient with non-metastatic skin melanoma (All stages except stage IV and stage III C inoperable)

Patient with another synchronous cancer, or within 3 years

Patient with a contraindication to blood collection of 20 mL

Patient deprived of liberty or under supervision

Patient unable to receive kinase inhibitor therapy

Patient treated with another combined kinase inhibitors than dabrafenib and trametinib

Pregnant or breastfeeding women

Patient (man or woman) of childbearing age who does not agree to use of contraceptive methods validated during the study

Therapeutic Drug Monitoring of BRAF-mutated Advanced Melanoma