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COMPLETEDNCT03416543

Effect of a New BI-specifiC Antibody Towards Dendritic Cells on Inflammation in Rheumatoid Arthritis

First, this study will evaluate, in vitro, the cellular composition of the synovial fluid from patient with rheumatoid arthritis, gout or osteoarthritis. Then samples will be test with a new format o...

Lead sponsor: University Hospital, Tours•1 locations•View source on ClinicalTrials.gov

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Lead Sponsor

University Hospital, Tours

Rheumatoid arthritis (RA) is one of the most common autoimmune disease in adult. It exists several drugs but none target dendritic cells even if it seems they play a major role in the physiopathology. One of the unit of research of Tours recently develop a new format of bispecific antibody which target dendritic cells. The first results in PBMC (unpublished yet) show an increase of the production of IL-10 In this study, we are going to first evaluate the cellular composition of synovial fluid from patients with RA and patients with gout (for the comparison, because the inflammatory mechanisms are different) and with osteoarthritis (comparison with a non inflammatory disease) Then, we will use this new antibody and evaluate the response by dosing Il-10, IL-6, IL-12, IL1B and IFNy The aim is to verify in vitro if, with this new drug, it is possible to reverse the inflammation and induce a tolerance.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Male or female over 18 years old
•Proven and possible RA or Gout or osteoarthritis
•Arthritis accessible to a puncture
•Necessary puncture for diagnosis or therapeutic

Exclusion Criteria

•Microcrystalline rheumatism other than Gout
•Known SpA
•Septic arthritis
•Biomedicament treatment
•Patient having objected to the processing of his data

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: December 23, 2021Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment45

Start dateDec 2017

Last updatedDec 23, 2021

Condition

Rheumatoid Arthritis Gout Osteoarthritis

Locations shown

Rheumatology Department, University Hospital, Tours

Tours

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 23, 2021Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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