Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Missouri-Columbia
Age
30–70
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Age: ≥30 and ≤70 years,
BMI: ≥30 and ≤45 kg/m2 or body fat ≥ 30 % for women and ≥ 25 % for men,
Maximum body circumference \<170 cm
Weight stable (≤2% change)
Untrained (≤1 h of structured exercise/wk) for at least 3 months before entering the study
No diabetes (fasting blood glucose \<126 mg/dl, 2h oral glucose tolerance test (OGTT) glucose \<200 mg/dl, HbA1c ≤6.5%)
Subjects without OSA:
AHI \<5/h of sleep;
Oxygen desaturation index \<3/h
No known sleep disorders and periodic limb movement arousal index \<15/h during polysomnography
Reported sleep duration ≥6 h per night
Regular sleep schedules (i.e. bedtime between 8 pm and 12 am and wake-time between 4 am and 8 am on all days of the week)
Subjects with OSA
AHI ≥10/h of sleep (i.e., moderate to severe OSA)
Oxygen desaturation index ≥4/h;
No polysomnogram finding that would trigger immediate PAP treatment as per standard operating protocol in our sleep medicine center (a single SaO2 \<50%, SaO2 \<70% for \>2 minutes, electrocardiogram pause \>5 sec, or ventricular tachycardia \>30 sec), because of the risk of a potentially adverse outcome if they are not randomized to the PAP group
Periodic limb movement arousal index \<15/h during polysomnography,
Reported sleep duration ≥6 h per night,
Regular night-time sleep schedules, defined as bedtime between 8 pm and 12 am and wake-time between 4 am and 8 am on all days of the week.
You may not be if
Current treatment for previously diagnosed OSA;
Self-reported severe difficulty sleeping in unfamiliar environments;
Metal implants that are incompatible with magnetic resonance imaging;
Controlled substances, tobacco products, dietary supplements, or medications known or suspected to affect sleep, breathing, upper airway muscle physiology, or glucose metabolism
Evidence of disease (e.g., diabetes, congestive heart failure; chronic obstructive pulmonary disease; hypoventilation, defined as daytime partial pressure of carbon dioxide (pCO2) \>45 mm Hg; major neurological or neuromuscular disorders; cancer; uncontrolled hypertension; etc.);
Contraindications to supplemental oxygen or PAP (e.g., recent trans-sphenoidal surgery).
Unwillingness or inability to provide informed consent
Study physician considers subject to be unable to safely complete the study protocol
Clareo Health | Obstructive Sleep Apnea and Glucose Metabolism
