Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease

Exclusion Criteria

• •Current cigarette smokers
• •Current participation in any investigational drug or device study. If subjects choose to participate in another investigational drug or device study, they will be discontinued from this study protocol.
• •Current pregnancy or nursing as indicated by self-report. While not a safety issue, pregnancy or nursing influences the biochemical composition of the tear film.
• •Any systemic health conditions that alter tear film physiology
• •A history of ocular surgery within the past 12 months
• •Any active ocular infection or inflammation
• •Any present use of Accutane or ocular medications
• •Any history of significant adverse reaction to lifitegrast or other components of the drug product, or contraindication to the use of lifitegrast or other components of the drug product
• •Any prior exposure to lifitegrast.
• •For normal and dry eye subjects, any history of contact lens wear within the past three months.
• •For contact lens wearers, any change of soft contact lens brand or care solutions within 30 days prior to screening or any anticipation of changing current type/brand of contact lenses or care solutions throughout the 84 day study
• •Any condition, which in the examiner's opinion, may put the subject at significant risk, confound study results, or interfere with their participation in the study.