Bioavailability of DHE Administered by I123 POD Device, IV Injection, and Migranal Nasal Spray in Healthy Adults

Exclusion Criteria

• •Subjects with a recent history of migraine and its variants including hemiplegic migraine and basilar migraine. A recent history of migraine is defined as (a) current or past history of migraine with at least 1 attack in last 6 months or (b) those receiving antimigraine prophylaxis.
• •Positive testing for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C antibodies (HCV).
• •Subjects who have ingested caffeine within 48 hours before admission on Day -1. Subjects must also agree to refrain from consumption of caffeinated drinks for 48 hours before admission of Days 7 and 14 (i.e. prior to each subsequent dosing), and throughout confinement.
• •Subjects with ischemic heart disease or subjects who have clinical symptoms or findings consistent with coronary artery vasospasm including Prinzmetal's variant angina.
• •Subjects with hypertension, known peripheral arterial disease, Raynaud's phenomenon, sepsis, history of vascular surgery or severely impaired hepatic or renal function
• •Subjects who have previously shown hypersensitivity to ergot alkaloids or metoclopramide.
• •Use of any relevant prescription, over-the-counter medication (with the exception of oral contraceptives), foods (e.g. grapefruit juice) or supplements (including herbal) within 14 days of randomization \[especially those affecting the Cytochrome P450 3A4 (CYP3A4) metabolic pathway\].
• •History or presence of alcoholism or drug abuse within the 2 years prior to the first investigational product administration.
• •Surgery within the past three months prior to the first investigational product administration as determined by the PI to be clinically relevant.
• •Active infection and/or use of macrolide antibiotics within 14 days prior to enrollment.
• •History of recurrent infections.
• •Any nasal congestion or physical blockage in either nostril, or deviated nasal septum as determined by nasal examination.