Study of Boserolimab (MK-5890) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Adults With Advanced Solid Tumors (MK-5890-001)

Exclusion Criteria

• •History of a second malignancy, unless potentially curative treatment has been completed with no evidence of malignancy for 2 years
• •Clinically active central nervous system metastases and/or carcinomatous meningitis
• •Has had a severe hypersensitivity reaction to treatment with a monoclonal antibody (mAb) and/or other components of the study treatment
• •Active infection requiring systemic treatment
• •History of interstitial lung disease
• •History of (noninfectious) pneumonitis that required steroids or current pneumonitis
• •Symptomatic ascites or pleural effusion
• •Previously had a stem cell or bone marrow transplant
• •Previously had a solid organ transplant
• •Active autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs) except vitiligo or resolved childhood asthma/atopy
• •Known human immunodeficiency virus (HIV) and/or active and acute Hepatitis B or C infections
• •Not fully recovered from any effects of major surgery without significant detectable infection
• •Pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study
• •Had chemotherapy, definitive radiation, or biological cancer therapy within 4 weeks (2 weeks for palliative radiation) before the first dose of study treatment, or has not recovered to Grade ≤1 or better from any AEs that were due to cancer therapeutics administered more than 4 weeks earlier
• •Expected to require any other form of antineoplastic therapy while participating in this study
• •On chronic systemic steroid therapy in excess of replacement doses (e.g., exceeding 10 mg/day of prednisone equivalent), or on any other form of immunosuppressive medication
• •Regular user (including "recreational use") of any illicit drugs at the time of signing informed consent, or has a recent history (within the last year) of substance abuse (including alcohol), as determined by the treating investigator. Participants who use cannabis for medicinal purposes or to treat specific symptoms will not be excluded unless it is being abused in the opinion of the treating investigator
• •Received a live-virus vaccine within 28 days before the first dose of study treatment
• •Currently participating and receiving study treatment in a study of an investigational agent or has participated and received study treatment in a study of an investigational agent or has used an investigational device within 28 days before the first dose of study treatment
• •Has received radiation therapy to the lung that is \>30 Gray (Gy) within 6 months before the first dose of study treatment
• •Is unable to interrupt aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), other than an aspirin dose ≤1.3 g per day, for a 5-day period (8-day period for long-acting agents, such as piroxicam).
• •Is unable or unwilling to take folic acid or vitamin B12 supplementation
• •Has a known history of hypersensitivity or allergy to nab-paclitaxel or any of its components
• •Has neuropathy ≥Grade 2
• •Has a history of class II-IV congestive heart failure or myocardial infarction within 6 months of randomization
• •Has received previous treatment with immune checkpoint inhibitor(s) (eg, Programmed Cell Death Receptor 1 (PD-1)/PD-L1)