Study of DCR-PHXC-101 in Normal Healthy Volunteers and Patients With Primary Hyperoxaluria

Exclusion Criteria

• •Presence of any medical condition, including but not limited to: Severe intercurrent illness, known causes of active liver disease.
• •Routine or chronic use of more than 3 grams of acetaminophen (Tylenol) daily.
• •History of kidney stones.
• •Use of any investigational agent within 90 days before the first dose of study medication.
• •History of donation of more than 450 mL of blood within 90 days prior to dosing in the clinical research center or planned donation less than 30 days after receiving Investigational Medicinal Product (IMP).
• •Plasma or platelet donation within 7 days of dosing and through EOS.
• •History of reactions to an oligonucleotide-based therapy.
• •Males with female partners who are planning to attempt to become pregnant during this study or within 90 days after last dosing of IMP.
• •Plasma or platelet donation within 7 days of dosing and through EOS.
• •Prior renal and/or hepatic transplantation.
• •Currently receiving dialysis.
• •Participation in any clinical study where they received an investigational agent within 4 months before enrollment.
• •Presence of any medical condition, including but not limited to: Severe intercurrent illness, known causes of active liver disease.
• •Liver function test (LFT) abnormalities.
• •History of reactions to an oligonucleotide-based therapy.