A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.

Exclusion Criteria

• •1. History of a medical or psychiatric disorder that would prevent successful completion of the study.
• •2. Current DSM-5 diagnosis of substance use disorders requiring medical management other than OUD.
• •3. Suicidal ideation or intent with or without a plan at Screening or within 6 months prior to Screening (i.e., answering "Yes" to questions 4 and/or 5 on the Suicidal Ideation section of the Columbia Suicide Severity Rating Scale).
• •4. Currently seeking or participating in treatment for substance use disorder.
• •5. Physically dependent on drugs of abuse (other than opioids, nicotine, or caffeine) or alcohol.
• •6. Medically important deviation from normal limits on physical examination, vital signs, screening laboratory tests, or 12--lead ECG.
• •7. Significant cardiovascular, hepatic, renal, respiratory, gastrointestinal, endocrine, immunologic, dermatologic, hematologic, or neurologic disorder.
• •8. Any surgical, or medical condition that may interfere with the absorption, distribution, metabolism, or excretion of the test drug.
• •9. Family history of long QT syndrome and/or unexpected sudden cardiac death or is known to have QTc \> 500 ms at screening.
• •10. Used an investigational agent within 30 days or 5 therapeutic half-lives of that agent, whichever is longer, prior to the first dose of study drug.
• •11. Hypersensitivity to opioids or any drug intended for use in this study.
• •12. Acute gastrointestinal symptoms (e.g., nausea, vomiting, fever, or Diarrhea unrelated to opioid withdrawal) ≤ 7 days before Day 1.
• •13. Any of the following values for laboratory tests at Screening:
• •1. A positive pregnancy test in women of childbearing potential.
• •2. Hemoglobin \< 11 g/dL in males and \< 10 gm/dL in females.
• •3. Neutrophil count \< 1.0 × 109/L.
• •4. Platelet count \< 75 × 109/L.
• •5. Creatinine clearance \< 50 ml/min per modified Cockcroft-Gault equation.
• •6. Aspartate aminotransferase or alanine aminotransferase \> 3.0x upper limit of normal.