Pregnant, planning to get pregnant, or nursing.

Claustrophobia

Cardiac pacemaker

Intracranial clips, metal implants, unremovable jewelries, metal in eyes.

History or presence of any other major medical, neurologic or psychiatric conditions, such as Alzheimer's diseases, Parkinson's diseases, and stroke.

Renal or liver disease as this may cause concerns related to Gad-based contrast agent

Allergy to the contrast agent Gadolinium

Developing Advanced Blood-Brain Barrier Permeability Imaging for Early AD