Clareo Health | High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia
High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Washington
OUTLINE:
Patients undergo collection of bone marrow aspirate and blood for high-throughput drug sensitivity assay and mutational analysis using next generation sequencing. Patients and their treating physicians receive the results of the tests. Treatment decisions are then made by the patients and their treating physicians.
After completion of study, patients are followed up every 3 months for 2 years.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Diagnosis of multiple myeloma or plasma cell leukemia with documented relapsed or refractory disease according to International Myeloma Working Group (IMWG) criteria, in any one of the following categories:
* 3 prior lines of therapy including an immunomodulatory drug (IMiD) and a proteasome inhibitor (PI)
* Less than a very good partial response (VGPR) to initial therapy
* Early relapse (\< 12 months) after autologous hematopoietic cell transplant (HCT) or after 1st line of therapy
Collection of a bone marrow, fluid or tissue sample that is expected to have enough cells to run the assay
Measurable disease defined by one of the following:
* Serum monoclonal protein \>= 0.5 g/dL by serum protein electrophoresis (SPEP)
* \>= 200 mg/monoclonal protein in urine on 24 hr urine protein electrophoresis (UPEP)
* Involved serum free light chain (FLC) \>= 10 mg/dL and abnormal involved:uninvolved ratio
* Plasma cytomas that are palpable per exam or measurable per standard radiologic review
* Circulating plasma cells \>= 2,000 if diagnosis of plasma cell leukemia
Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-3
Female patients of child bearing potential and non-vasectomized male patients agree to practice appropriate methods of birth control
Ability to understand purpose and risks of the study and provide signed and dated informed consent, and authorization to use protected health information
Expected survival is \> 100 days
Adequate organ function as determined by the investigator
You may not be if
Mucosal or internal bleeding, or platelet transfusion refractory
Any medical conditions that would impose excessive risk to the patient, or would adversely affect his/her participation in the study
Known active infection requiring antibiotics within 7 days of initiation of study treatment, unless considered controlled in the opinion of the investigator
Other malignancy with life expectancy \< 1 year due to the other malignancy
Pregnant or breast feeding women
Serious psychiatric illness, alcoholism, or drug addiction
Human immunodeficiency virus (HIV), or active hepatitis B or C infection
Previous treatments for multiple myeloma (MM) within 2 weeks of initiation of study treatment
Prior autologous or allogeneic stem cell transplantation (SCT) within 12 weeks of initiation of study treatment
Prior allogeneic hematopoietic cell transplantation (HCT) with active graft versus host disease (GVHD) on therapeutic dosing of immunosuppression or prednisone \> 20 mg daily equivalent
Prior major surgical procedure or radiation treatment within 2 weeks of initiation of study treatment (not including limited radiation used for palliation of bone pain)
