contraindications of intravenous iron therapy: iron allergy, active infection, hemochromatosis, iron overload (serum ferritin \> 500 ng/mL and/or transferrin saturation \> 50%);

treatment with iron and erythropoiesis-stimulating agents (at the time of recruitment and 6 months previously);

active smoker status;

antioxidant food supplements treatment in the last 3 months;

clinically manifest bleeding;

another cause of anemia (hemoglobinopathies, vitamin B12 and/or folic acid deficiency suggested by the megaloblastic peripheral blood smears's appearance, multiple myeloma and other paraproteinemias);

severe anemia (Hb \< 7 g/dl);

baseline FMD \< 7% (the existence of atherosclerosis which limits arterial reactivity);

cancer (currently or in the past 6 months);

hepatopathies (increased serum transaminases ≥ 3 x normal value) or hepatic impairment ≥ grade Child B;

autoimmune disorders or significant inflammation (as defined by C-reactive protein \> 5 mg/L);

pregnancy or lactation;

participation in other clinical trials over the upast 3 months;

patient unwillingness.

Acute Effects of Intravenous Iron on Oxidative Stress and Endothelial Dysfunction in Non-dialysis CKD

What this study is about