Trial of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab

Exclusion Criteria

• •Congenital hemophilia
• •Ongoing treatment with prednisone \> 20mg/d （or equivalent corticosteroid doses） more than 1 month
• •Ongoing treatment with prednisone \>0.7mg/kg（or equivalent corticosteroid doses） more than 10 days
• •Pregnant and breastfeeding women
• •Allergy to steroid
• •Immunosuppressive agents treatment within 30 days
• •Serum transaminase and bilirubin greater than 1.5 times the upper limit of normal value
• •Hepatitis B surface antigen or hepatitis C antibody or HIV antibody (I + II) or syphilis antibody positive
• •Patients with diabetes, hypertension, glaucoma, peptic ulcer, herpes zoster, pulmonary infection and so on, who should not be treated with glucocorticoids
• •Patients with poor compliance
• •Those who can not take contraceptive measures during the test period
• •Patient who is considered by the investigator not suitable for clinical study
• •Thrombocytopenia
• •Leucocytopenia