Sleep and Inflammatory Resolution Pathway

Exclusion Criteria

• •Active infection/disease.
• •Following blood chemistry values outside of the laboratory's normal range or the range specified below:
• •* WBC (range: 2.0-10.0 K/uL)
• •* Platelet count
• •* Hematocrit in range
• •* TSH outside of the laboratory's normal range
• •* Bilirubin \>1.5 upper limit of normal
• •* ALT or AST \>2.5 upper limit of normal
• •Stage 4 chronic kidney disease based on CKD epi-equation
• •Pre-diabetes or diabetes (HbA1c \>5.7%)
• •History of neurological, chronic pain, immune/inflammatory, vascular/cardiovascular (including Raynaud syndrome), liver/kidney, metabolic disorders (including diabetes).
• •Current asthma (diagnosis of asthma and either asthma symptoms present within the past years or taking medication for asthma) and/or history of ASA induced sensitivity
• •Systolic blood pressure ≥ 140mmHg and/or diastolic blood pressure ≥ 90 mmHg prior to the initial and medical screens. Systolic blood pressure ≥ 160mmHg and/or diastolic blood pressure ≥ 100mmHg during admissions (Stays 1, 2, and 3)
• •History of gastrointestinal disorders, including esophageal reflux, gastric and duodenal ulcers, gastrointestinal bleeding.
• •Personal or family (first degree relative) history of any stroke
• •History of psychiatric disorders, including major depressive disorders, bipolar disorders, panic disorders, post-traumatic stress disorders (PTSD), thought disorders, and substance abuse/dependence disorders.
• •History of intolerance or allergy to non-steroidal anti-inflammatory drugs (NSAID).
• •Sleep disorders: Sleep efficiency \<80% based on polysomnographic (PSG) screening night; respiratory disturbance index of \>10 events/hour based on PSG screening night, periodic leg movement index (PLMI) of \>25/hour and/or PLMAI (PLM arousal index) of \>5/hour based on PSG screening night; restless legs syndrome, circadian rhythm disorders, and nightmare disorders determined by diagnostic interview.
• •Pregnant/nursing.
• •Regular medication use other than oral contraceptives.
• •Intake of non-steroidal anti-inflammatory drugs (NSAIDs) or cold/cough remedies within the last month.
• •Intake of dietary supplements containing DHA/EPA-derived fatty acids (e.g., fish oil) within the last 3 months prior to study start.
• •Donation of blood or platelets within three months prior to or in-between study arms.
• •Smoking.