Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Akcea Therapeutics
With
Ionis Pharmaceuticals, Inc.
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Plasma triglycerides (TG) at Screening greater than (\>)150 milligrams per deciliter (mg/dL) and at qualification of \>150 mg/dL.
Documented history of hepatic steatosis with baseline magnetic resonance imaging (MRI) indicating hepatic fat fraction (HFF) greater than (\>) 8%.
Diagnosis of Type 2 diabetes mellitus with hemoglobin A1c (HbA1c) \>6.5 and less than or equal to (≤) 10% at Screening.
Must have been on a stable dose of oral antidiabetic therapy for a minimum of 3 months prior to Screening.
Body mass index between 27- 40 kilograms per meter square (kg/m\^2), inclusive, at Screening.
You may not be if
Type 1 diabetes mellitus.
Active chronic liver disease, alcoholic liver disease, Wilson's disease hemochromatosis, primary biliary cirrhosis, primary sclerosing cholangitis, genetic hemochromatosis, known or suspected hepatocellular carcinoma, history of or planned liver transplant for end-stage liver disease of any etiology.
Documented history of advanced liver fibrosis.
History of cirrhosis and/or hepatic decompensation including ascites, hepatic encephalopathy, or variceal bleeding.
History of clinically significant acute cardiac event within 6 months before Screening.
History of heart failure with New York Heart Association (NYHA) greater than Class II.
Use of Insulin or insulin analogs, glucagon-like peptide-1 (GLP-1) agonists, and peroxisome proliferator-activated receptor gamma (PPARᵞ) agonists (pioglitazone or rosiglitazone).
Weight change \>5% within 3 months before Screening.
Conditions contraindicated for magnetic resonance imaging (MRI) procedures including any metal implant (example, heart pacemaker, rods, screws, aneurysm clips).
Clareo Health | Study of ISIS 703802 in Participants With Hypertriglyceridemia, Type 2 Diabetes Mellitus, and Nonalcoholic Fatty Liver Disease
