Immediate Reconstruction and Dental Rehabilitation of Maxillofacial Defects

The primary goal of any reconstructive procedure is to restore a patient's natural form and function. The new techniques implemented in this study will demonstrate an approach that allows immediate return of the patient's premorbid state in one procedure. The investigators have demonstrated success with a small cohort of patients, and published a recent case study regarding this new technique. This study is meant to build upon the investigators experiences and advance their process and treatment of these patients. With a larger patient population to study, greater data can be obtained, with the ultimate goal of establishing this treatment as a new standard of care for patients with large ablative defects requiring reconstruction. Patients with benign, large tumors requiring surgical resection with free tissue transfer reconstruction involving the maxilla and mandible will be included in the study. All of the patients will undergo the following pre-operative protocol: * CT Maxillofacial Region * CTA * Dental impression (intra-oral scan and/or impressions) * Virtual surgical planning * Patient specific plate fabrication * Resection and flap harvest osteotomy guides * Fabrication of screw-retained provisional prosthesis Surgical treatment protocol involves: * Resection of benign tumor using osteotomy guides * Reconstruction with free tissue (osseous free flap) transfer using osteotomy guides * Placement of dental implants (minimum of three) using integrated osteotomy and implant placement guide * Placement of provisional screw-retained prosthesis (all while flap is still pedicled to vascular supply) * Inset of flap/implant/prosthesis/custom plate construct * Vascular anastomosis and closure Immediate post-operative management will include a 5-to-7 day post-operative hospital stay and a post-operative CT scan evaluation. Long-term evaluation of patients will include routine clinical exams and cone beam CT scans to evaluate flap and implant survival. Patients, for the purpose of this study, will be followed for one year following placement of final dental prosthesis (18-24 months post-operatively).