Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Gladwin, Mark, MD
With
National Heart, Lung, and Blood Institute (NHLBI)
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Ages 18 years and older
Weight ≥110 lbs
Hemoglobin ≥ 12.5 g/dL or hematocrit ≥ 38% for women and hemoglobin ≥ 13.0 g/dL or hematocrit ≥ 39% for men.
Meet criteria for autologous blood donation
You may not be if
Subjects with a past medical history or symptoms of blood dyscrasia, diabetes mellitus, hyperlipidemia, obstructive sleep apnea, renal disease, congestive heart failure, significant cardiac disease and / or known peripheral arterial disease.
Moderate to severe systemic hypertension (systolic blood pressure \>140 mmHg and/or diastolic blood pressure \> 95 mmHg
Systolic blood pressure \<100 mmHg and/or diastolic blood pressure \< 60 mmHg on the study day.
Positive Direct Antiglobulin Test
Consumption of biotin supplements or raw eggs within 30 days
Treatment with antibiotics in the week before initiating study participation to avoid suppression of erythropoiesis, which may accompany infection.
Blood loss in the previous 8 weeks due to epistaxis, trauma, hemoptysis, gastrointestinal bleeding, diagnostic phlebotomy (\> 30 ml)
Subjects who report tobacco or marijuana smoking within 6 months of study.
Cognitively impaired subjects, or institutionalized persons and subjects unable or unwilling to complete written informed consent
Subjects with a history of blood donation within the last 56 days.
Use of other investigational drugs/devices within 30 days of screening.
Subjects taking any medication for the treatment of diabetes including insulin
Females of childbearing potential who are pregnant or unwilling to undergo pregnancy testing; females with positive pregnancy testing on screening day will be excluded.
History of prior transfusion reaction to blood products.
Allergic reaction to biotin
Donors with naturally occurring antibodies against BioRBCs will be excluded from the study
Clareo Health | Transfusion of Biotin-Labeled Red Blood Cells
