A Clinical Method Development Study to Characterise The Efficacy of a Dentifrice For The Relief Of Dentin Hypersensitivity

Exclusion Criteria

• •An employee of the investigational site directly involved in the conduct of the study or a member of their immediate family; an employee of the investigational site otherwise supervised by the investigator; a GSK employee directly involved in the conduct of the study or a member of their immediate family.
• •Participation in other studies (including cosmetic studies) involving investigational drug(s) within 30 days of study entry and/or during study participation.
• •Participation in another tooth desensitizing treatment study within 8 weeks Screening.
• •Acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the participant inappropriate for entry into this study.
• •Any condition which, in the opinion of the investigator, causes xerostomia.
• •Pregnant female participant (as evidenced by a positive urine pregnancy test).
• •Breastfeeding female participant.
• •Known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients.
• •Recent history (within the last year) of alcohol or other substance abuse.
• •Dental prophylaxis within 4 weeks of Screening.
• •Tongue or lip piercing or presence of multiple dental implants.
• •Gross periodontal disease, treatment of periodontal disease (including surgery) within 12 months of Screening, scaling or root planning within 3 months of Screening.
• •Participant with evidence of gross intra-oral neglect or the need for extensive dental therapy.
• •Teeth bleaching within 8 weeks of Screening.
• •Participant with fixed or removable partial dentures.
• •Participant with fixed or removable orthodontic braces/bands or a fixed orthodontic retainer.
• •Specific exclusions for test teeth: a) Tooth with evidence of current or recent caries, or reported treatment of decay within 12 months of Screening, b) Tooth with exposed dentin but with deep, defective or facial restorations, c) Teeth with full crowns or veneers, d) Sensitive teeth with contributing etiologies other than erosion, abrasion or recession of exposed dentin, e) Sensitive tooth not expected to respond to treatment with an over-the-counter dentifrice in the opinion of the investigator.
• •Use of an oral care product indicated for the relief of dentin hypersensitivity within 8 weeks of Screening (participant will be required to bring their current oral care products to the site in order to verify the absence of known anti-sensitivity ingredients).
• •Daily doses of medication/treatments which, in the opinion of the investigator, could interfere with the perception of pain. Examples of such medications include analgesics, anticonvulsants, antihistamines that cause marked or moderate sedation, sedatives, tranquilizers, anti-depressants, mood-altering and anti-inflammatory drugs.
• •Use of antibiotics in the 2 weeks prior to the Screening visit, or in the 2 weeks prior to the Baseline visit during the acclimatization period.
• •Daily dose of a medication which, in the opinion of the investigator, is causing xerostomia.
• •Participant who requires antibiotic prophylaxis for dental procedures.
• •Participant who is unwilling or unable to comply with the Lifestyle/Study Restrictions described in the study protocol.
• •Participant who has previously been enrolled in this study.
• •Any participant who, in the judgment of the investigator, should not participate in the study.