Patients with the usual contraindications to MRI (pace-maker, agitation, metal splinters, claustrophobia etc.)

Patients at risk of non-compliance on examination: impaired understanding, confusion, involuntary movements, poor tolerance of prolonged supine

Patients with known allergy to gadolinium

Patients with renal insufficiency

Patients unable to give their consent: disorders of the comprehension, disturbances of vigilance, confusion ...

Pregnant and breastfeeding woman

Patients with a history of neurological or psychiatric pathology

Patients under guardianship or curatorship

MRI Study of the Mechanisms Underlying Irreversible Disability in Multiple Sclerosis