Rising prostate-specific antigen (PSA) (at least two consecutive rising PSAs) after definitive therapy with prostatectomy or radiation therapy (external beam or brachytherapy).
* Post radical prostatectomy (RP) - American Urological Association (AUA) recommendation for biochemical recurrence after radical prostatectomy
* PSA greater than or equal to 0.2 ng/mL measured more than 6 weeks after RP.
* Post-radiation therapy -ASTRO-Phoenix consensus definition of biochemical recurrence after radiation therapy
* Nadir + greater than or equal to 2 ng/mL rise in PSA
Karnofsky performance status of \> 50 (or Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) equivalent).
Age \>= 18.
Ability to understand a written informed consent document, and the willingness to sign it.
You may not be if
Unable to lie flat, still or tolerate a PET scan.
Concomitant investigational therapy.
Patient undergoing active treatment for non-prostate malignancy, other than skin basal cell or cutaneous superficial squamous cell carcinoma that has not metastasized and superficial bladder cancer.
