Lead Sponsor

University of Edinburgh

Age

70 - No limit years

Sex

ALL

Healthy Volunteers

Yes

•Severe aortic stenosis
•Referred for aortic valve intervention (surgical AVR / TAVI)
•High clinical suspicion of amyloid (e.g. low-flow low-gradient AS, inappropriate LVH)
•Age \>70 years
•Willing and able to comply with study protocol
•No symptoms suggesting current cardiovascular disease
•Age \>70
•Willing and able to comply with study protocol

•Inability to give informed consent
•Contraindication to MRI scanning (e.g. permanent pacemaker)
•Significant renal impairment (eGFR \<30 ml/min/1.73 m2)
•Coexistent moderate or severe aortic regurgitation or mitral stenosis
•Acute valvular heart disease (e.g. acute mitral regurgitation or endocarditis)
•Acute pulmonary oedema or cardiogenic shock
•Inability to give informed consent
•Contraindication to MRI scanning (e.g. permanent pacemaker)
•Significant renal impairment (eGFR \<30 ml/min/1.73 m2)
•Known significant valvular heart disease (more than mild regurgitant valve lesion or any stenotic lesion)