Histological confirmed adenocarcinoma of the colon or rectum with metastatic disease not amenable to salvage surgery.
Planned primary treatment at FUNNEL center or FUNNEL center referring Hospital.
Availability of fresh tissue or a paraffin block for genotyping NOT older than 1 year.
Age ≥18.
ECOG PS 0-1.
No major comorbidities that would preclude the potential enrolment of the patient in a clinical trial.
Signed informed consent.
You may not be if
Symptomatic brain metastases.
Gastro-intestinal abnormalities, inability to take oral medication, any condition affecting absorption.
History of another neoplastic disease (except basal cell carcinoma of the skin or uterine cervix carcinoma in situ adequately treated), unless in remission for ≥ 5 years.
No major comorbidities that would preclude the potential enrolment of the patient in a clinical trial.
