Efficacy of Polygonatum Sibiricum on Sleep Quality Improvement

Exclusion Criteria

• •Diagnosed with insomnia assessed with a structured interview and sleep scale measurements
• •Possibility of drug-induced sleep disorders due to current intake of medication (i.e., corticosteroid, statin, etc)
• •Had taken sleeping pills (i.e., zolpidem, benzodiazepine) during the past 2 months
• •Diagnosed with any major medical or neurological disorders assessed during medical history taking, physical examination or experimental tests.
• •Diagnosed with any axis 1 psychiatric disorders (depressive disorder, bipolar disorder, alcohol dependence, schizophrenia) evaluated with a structured instrument
• •A history of traumatic brain injury with loss of consciousness, or any contraindications to MRI (i.e., claustrophobia, metallic foreign devices in body)
• •Had taken psychotropic drugs within the past 3 months before study participation
• •Allergic to polygonatum sibiricum or experienced side effects after consumption of any product containing polygonatum sibiricum
• •Participated in another clinical trial or took other medications during the period that may influence the results of this clinical trial
• •Currently taking contraceptive pills
• •Planning for pregnancy during the period of study participation, currently pregnant or breastfeeding