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The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users | Clinical Trials | Clareo Health

COMPLETEDPHASE1

The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users

NCT03335163•University of Colorado, Denver

View on ClinicalTrials.gov

Summary

A prospective, non-inferiority study to evaluate the pharmacokinetic effect of topiramate on serum Etonogestrel (ENG) levels in contraceptive implant users.

Eligibility

Age

18 - 45 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•Healthy women, who have had an ENG implant for 12-36 months at the time of enrollment;
•Will maintain their implant during the study without modifications.

Exclusion Criteria

•Women who are taking any medications or supplements known to be
•1. Cytochrome P-450 enzyme inducers, inhibitors, or substrates, and
•2. are not willing to abstain from any of these medications or supplements during the entire course of the study.
•Women with liver disease (i.e. hepatitis, fatty liver disease), and
•Women with abnormal liver or renal function, or
•Women with abnormal electrolytes on their screening blood work.

Locations (1)

University of Colorado Denver

Aurora, Colorado, United States

Key Dates

Start Date

March 15, 2018

Primary Completion Date

April 22, 2021

Completion Date

April 22, 2021

Last Updated

July 13, 2022

Enrollment

ACTUAL participants

Conditions

MigraineMigraine;MenstrualContraception

Interventions

Topiramate

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 13, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users

Inclusion Criteria

Exclusion Criteria

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

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