Effect of Egg Consumption on Cardiometabolic Health in Prediabetic Subjects.

Exclusion Criteria

• •1. Atherosclerotic cardiovascular disease including any of the following:
• •clinical signs of atherosclerosis including peripheral arterial disease, abdominal aortic aneurysm, carotid artery disease \[symptomatic (e.g., myocardial infarction, angina, transient ischemic attack or stroke of carotid origin) or \>50% stenosis on angiography or ultrasound\] or other forms of clinical atherosclerotic disease (e.g., renal artery disease).
• •2. History or presence of clinically important pulmonary (including uncontrolled asthma), endocrine (including type 1 or 2 diabetes mellitus), chronic inflammatory disease (including irritable bowel disease, lupus, rheumatoid arthritis), hepatic, renal, hematologic, immunologic, neurologic, or biliary disorders.
• •3. Known allergy, sensitivity, or intolerance to any ingredients in the study foods.
• •4. Uncontrolled hypertension
• •5. Recent history of cancer in the prior 5 years, except for non-melanoma skin cancer.
• •6. Recent change in body weight of ±4.5 kg.
• •7. Unstable use of any antihypertensive medication.
• •8. Recent use of any medications intended to alter the lipid profile \[e.g. bile acid sequestrants, cholesterol absorption inhibitor, fibrates, niacin (drug form), omega-3-ethyl ester drugs, and/or proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors\], weight-loss drugs, systemic corticosteroid drugs, medications known to influence carbohydrate (CHO) metabolism \[e.g. adrenergic receptor blockers, thiazide diuretics, hypoglycemic medications\], and/or anti-psychotics.
• •9. Recent use of foods or dietary supplements that might influence lipid metabolism \[e.g. omega-3 fatty acid supplements (e.g., fish or algal oils) or fortified foods, sterol/stanol products; dietary supplements (red rice yeast supplements; garlic supplements; soy isoflavone supplements; niacin or its analogues at doses \>400 mg/d\], inconsistent use of Metamucil® or viscous fiber-containing supplements
• •10. Use of antibiotics within 5 days of screening.
• •11. Pregnant, planning to be pregnant during the study period, lactating, or of childbearing potential and unwilling to commit to the use of a medically approved form of contraception throughout the study period.
• •12. Extreme dietary habits (e.g., vegan or very low carbohydrate diet).
• •13. Current or recent history or strong potential, for drug or alcohol abuse.
• •14. History of a diagnosed eating disorder (e.g., anorexia or bulimia nervosa).
• •15. Recent exposure to any non-registered drug product.