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Short Term Choline and Cardiovascular Health | Clinical Trials | Clareo Health

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COMPLETEDNANCT03327805

Short Term Choline and Cardiovascular Health

Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be pred...

Lead sponsor: Virginia Polytechnic Institute and State University•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Virginia Polytechnic Institute and State University

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•18-65 years old, healthy, non-smoking weight stable for previous 6 months (±2.0 kg), BMI\<35 kg/m\^2, verbal and written informed consent, approved for participation by study medical director (Jose Rivero, M.D.)

Exclusion Criteria

•Smoking, pregnancy, obese (BMI\>35 kg/m\^2), altered dietary patterns within the last month of recruitment, vegetarians, vegans, unstable heart disease or diabetes, untreated high blood pressure or high cholesterol, allergies to choline supplement, taking any medications that could affect the results (ex., aspirin, antibiotics, pre/probiotics 1 month prior to enrollment), those with trimethylaminuria

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 27, 2026Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment20

Start dateMay 2019

Last updatedMar 27, 2026

Condition

Cardiovascular Risk Factor

Locations shown

Virginia Polytechnic and State University

Blacksburg, Virginia

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 27, 2026Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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