The Effect of Benralizumab on Exercise-induced Bronchoconstriction

Exclusion Criteria

• •1. Respiratory tract infection within 6 weeks preceding enrolment;
• •2. Asthma exacerbation in the last month;
• •3. Use of prednisone in the last 30 days;
• •4. Current lung disease other than moderate to severe eosinophilic asthma;
• •5. History of clinically significant hypotensive episodes or symptoms of fainting, dizziness, or light headedness, as judged by the investigator;
• •6. Any history or symptoms of uncontrolled cardiovascular disease, particularly coronary artery disease, arrhythmias, hypertension, or congestive heart failure;
• •7. Any history or symptoms of significant neurologic disease, including transient ischemic attack (TIA), stroke, seizure disorder, or behavioural disturbances;
• •8. Any history or symptoms of clinically significant autoimmune disease;
• •9. Any history of clinically significant haematologic abnormality, including coagulopathy or any history of chronic treatment with anti-coagulants (e.g. warfarin, etc.) or anti-platelet agent (e.g. aspirin, etc.);
• •10. Clinically significant abnormalities in laboratory test results at enrolment and during the screening period (including complete blood count, coagulation, chemistry panel and urinalysis) unless judged not significant by the investigator;
• •11. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) level ≥2.5 times the upper limit of normal (ULN) confirmed during screening period;
• •12. Being pregnant or lactating or have positive serum pregnancy test at enrolment or positive urine pregnancy test during the study;
• •13. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) 72 hours before or aspirin prn within 7 days of enrolment (Visit 1), as judged by the investigator;
• •14. Current smokers. Ex-smokers must not have smoked for a minimum of 12 months, and should not have a smoking history ≥10 pack years. Subjects who administer nicotine in other forms (patches, chew tobacco, etc.) will also be excluded from the study;
• •15. Concomitant disease or condition which could interfere with the conduct of the study, or for which the treatment might interfere with the conduct of the study, or which would, in the opinion of the investigator, pose an unacceptable risk to the subject in this study, including, but not limited to, cancer, alcoholism, drug dependency or abuse, or psychiatric disease;
• •16. History of cancer in last 5 years:
• •17. Alcohol or drug abuse (past or present);
• •18. Subject who is scheduled to be admitted to hospital or undergo in-subject surgery during the study;
• •19. History of anaphylaxis to any biologic therapy or vaccine;
• •20. History of Guillain-Barré syndrome;
• •21. A helminth parasitic infection diagnosed within 24 weeks prior to the date informed consent is obtained that has not been treated with, or has failed to respond to standard of care therapy;
• •22. Positive hepatitis B surface antigen, or hepatitis C virus antibody serology, or a positive medical history for hepatitis B or C. Subjects with a history of hepatitis B vaccination without history of hepatitis B are allowed to enrol;
• •23. A history of known immunodeficiency disorder including a positive human immunodeficiency virus (HIV) test;
• •24. Use of immunosuppressive medication (including but not limited to: methotrexate, troleandomycin, cyclosporine, azathioprine, intramuscular long-acting depot corticosteroid, oral corticosteroid, or any experimental anti-inflammatory therapy) within 3 months prior to the date informed consent is obtained;
• •25. Receipt of immunoglobulin or blood products within 30 days prior to the date informed consent is obtained;
• •26. Receipt of any marketed (e.g. omalizumab) or investigational biologic within 4 months or 5 half-lives prior to randomization is obtained, whichever is longer;
• •27. Receipt of live attenuated vaccines 30 days prior to the date of randomization
• •\- Receipt of inactive/killed vaccinations (e.g., inactive influenza) are allowed provided they are not administered within 1 week before/after any IP administration.
• •28. Previously received benralizumab (MEDI-563);
• •29. AstraZeneca staff involved in planning and/or conducting the study;