Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Jordan
Umbilical cord derived MSCs bank will be generated and all patients given the same cells from the same biological sample.
Thorough clinical, cognitive and motor analysis will be performed at baseline and compared to outcomes at 3 different time points of all enrolled patients.
The study will consist of three arms: 1- Stem cells treatment 2- Stem cells and supervised physical therapy 3- Supervised physical therapy
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
A clinical diagnosis of definite MS according to the revised McDonald Criteria.
Expanded Disability Status Scale (EDSS) ≤ 7
Failure of standard medical therapy
Disease duration of at least three years prior to enrollment.
You may not be if
Pregnant and lactating women
Previous treatment with immunosuppressive agents in the last 12 months prior to enrollment
Recent MS relapse in the month prior to enrollment
Treatment with oral or parenteral steroids for any cause in the month prior to enrollment
Significant systemic medical disorders including cardiac, renal, hepatic, hematologic, immunologic or endocrine disorders
Previous treatment with interferons or glatiramer acetate in the 3 months prior to enrollment
Any contra-indication for magnetic resonance imaging (MRI) or gadolinium contrast.
Positive serology for HIV, Hepatitis B or Hepatitis C
Any history of malignancy or exposure to radiation at any time prior to enrollment
Any contra-indication to lumbar puncture
Severe cognitive impairment that would interfere with the patient's ability to understand and sign the informed consent.
