Safety and Efficacy of Chlorthalidone in Type 1 Diabetes

Exclusion Criteria

• •BMI \> 99th percentile for age (\<18 years) or BMI \>35 kg/m2 (≥ 18 years)
• •Coexistent conditions that may affect calcium metabolism including:
• •* celiac disease
• •* Graves' Disease
• •* Addison's disease
• •* hypo- or hyperparathyroidism
• •History of diabetes related complications including:
• •* neuropathy
• •* retinopathy
• •* nephropathy
• •* gastroparesis
• •History of oral or inhaled corticosteroid use for ≥ 5 consecutive days within the past month
• •History of any diuretic use within the past month
• •Laboratory abnormalities on screening bloodwork including:
• •* estimated glomerular filtration rate \<90 mL/min per 1.73 m2 of body surface area
• •* serum calcium \>10.5 mg/dL
• •* serum potassium \<3.5 mmol/L
• •Systolic or diastolic blood pressure \<5th percentile for age and sex50 for age \<18 years or systolic \<90 mmHg or diastolic blood pressure \<60 mmHG for age ≥18 years