Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI

The study will characterize ventilation and gas transfer distributions in GOLD II and III COPD patients and assess the potential for these physiological parameters as a novel phenotyping method using Magnetic resonance imaging (MRI) using inhaled hyperpolarized 129Xe gas. The study will additionally quantify regional ventilation and gas transfer response to glycopyrrolate/formoterol in GOLD II and III COPD patients.

Age

40–any

Sex

ALL

Healthy volunteers

Not accepted

You may be eligible if

Clinical diagnosis of COPD confirmed by post-bronchodilator spirometry demonstrating (forced expiratory volume at 1 second(FEV1)/forced vital capacity (FVC) \< 0.70 and forced expiratory volume at 1 second (FEV1) in GOLD 2 or 3 stage (30%≤ (forced expiratory volume at 1 second \[FEV1\] \< 80%)
Willing and able to give informed consent and adhere to visit/protocol schedules
Women of childbearing potential must have a negative urine pregnancy test

You may not be if

Upper respiratory tract infection within 6 weeks
Chronic systemic corticosteroid use \> 10 mg/day of prednisone
* Chronic oxygen use (intermittent or continuous)
* Previous lung resection surgery or decortication
* Previous history of pneumothorax
* Evidence of interstitial, occupational or chronic infectious lung disease by imaging studies
* History of exposure to occupational or environmental hazards that are known to cause lung diseases
* For women of child bearing potential, positive pregnancy test
* Major chronic illnesses which in the judgement of the study physician would interfere with participation in the study
* Patients who are not willing to withhold COPD inhalers for the run-in period.
* MRI is contraindicated based on responses to MRI screening questionnaire
* Subject is pregnant or lactating
* Respiratory illness of a bacterial or viral etiology within 30 days of MRI
* Subject has any form of known cardiac arrhythmia
* Subject does not fit into 129Xe vest coil used for MRI
* Subject cannot hold his/her breath for 15 seconds
* Subject deemed unlikely to be able to comply with instructions during imaging

Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI

What this study is about

Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI

What this study is about