PGC-1 & MUSCLE MITOCHONDRIAL DYSFUNCTION IN DIABETES: AIMS 1-4

Inclusion Criteria

• •Aims 1-3.
• •1. Age 30-59
• •2. BMI: Lean, BMI less than or equal to 25; Obese, BMI between 30- 50; type 2 diabetic, BMI between 30- 50.
• •3. Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
• •4. Subjects may be of either sex with age as described in each protocol. Female subjects must be non-lactating and will be eligible only if they have a negative pregnancy test throughout the study period.
• •5. Subjects must range in age as described in each specific protocol.
• •6. Subjects must have the following laboratory values:
• •1. Hematocrit ≥ 35 vol%
• •2. Serum creatinine ≤ 1.6 mg/dl
• •3. AST (SGOT) \< 2 times upper limit of normal
• •4. ALT (SGPT) \< 2 times upper limit of normal
• •5. Alkaline phosphatase \< 2 times upper limit of normal
• •6. Triglycerides \< 150 mg/dl for nondiabetics (except for Aim 4).
• •7. Triglycerides \<300 for diabetics (except for Aim 4)
• •8. INR ≤ 1.3 Aim 4
• •1\. Age 30-59 2. BMI: Lean, BMI less than or equal to 25; Obese, BMI between 30- 50. 3. Patients may have normal or impaired glucose tolerance. 4. Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
• •5\. Subjects may be of either sex with age as described in each protocol. Female subjects must be non-lactating and will be eligible only if they have a negative pregnancy test throughout the study period.
• •6\. Subjects must have the following laboratory values:
• •1. Hematocrit ≥ 35 vol%
• •2. Serum creatinine ≤ 1.6 mg/dl
• •3. AST (SGOT) \< 2 times upper limit of normal
• •4. ALT (SGPT) \< 2 times upper limit of normal
• •5. Alkaline phosphatase \< 2 times upper limit of normal
• •6. Triglycerides \> 300 mg/dl for nondiabetics, \> 250 mg/dl for impaired glucose tolerance.
• •7. INR ≤ 1.3 7. Patients must be prescribed gemfibrozil from their doctor