A Study of Apatinib Plus Radiotherapy and S-1 for Treatment of Refractory or Metastatic Esophageal Squamous Cell Carcinoma

Inclusion Criteria

• •1\. Age:18 to 70 years old (man or female); 2. Imageology diagnosed with refractory or metastatic esophageal squamous cell carcinoma(pathologically diagnosed with supraclavicular lymph node metastasis and anastomotic recurrence ); 3. The distant metastatic is oligotransfera, with radiotherapy indication; 4. Patients with measurable lesions(measuring≥10mm on spiral CT scan, satisfying the criteria in RECIST1.1); 5. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2; 6. Major organ function has to meet the following certeria:
• •1. For results of blood routine test (without blood transfusion within 14 days)
• •1. HB≥100g/L;
• •2. ANC≥3.0×109/L;
• •3. PLT≥100×109/L;
• •2. For results of blood biochemical test：
• •1. TBIL\<1.5×ULN；
• •2. ALT and AST\<2.5×ULN, but\< 5×ULN if the transferanse elevation is due to liver metastases；
• •3. Serum creatinine ≤1ULN , calculated creatinine clearance\>50 ml/min(per the Cockcroft-Gault formula); 7. Life expectancy greater than or equal to 3 months; 8. Women of childbearing age must have contraceptive measures or have test pregnancy (serum or urine) enroll the study before 7 days, and the results must be negative, and take the methods of contraception during the test and the last to have drugs after 8 weeks. Men must be contraception or has sterilization surgery during the test and the last to have drugs after 8 weeks; 9. Coagulation function is normal, without active hemorrhage and thrombosis:
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• •1. INR\<1.5×ULN
• •2. APTT\<1.5×ULN
• •3. PT\<1.5ULN 10. Participants were willing to join in this study, and written informed consent; 11. Participants were good adherence, cooperate with the follow-up.