Hypofractionated Radiation Therapy With Concomitant Boost in Treating Women After Breast Conserving Surgery

Exclusion Criteria

• •breast cancer with stage III/III (AJCC 7th)
• •occult breast cancer
• •in-situ breast carcinoma
• •bilateral breast cancer
• •male breast cancer
• •breast lymphoma or breast sarcoma
• •combined with Paget's disease
• •received preoperative treatment(including neoadjuvant chemotherapy, endocrine therapy and target therapy
• •positive surgical margin
• •axillary lymph nodes dissection or sentinel lymph node biopsy omitted
• •regional lymph nodes radiation needed
• •boost volume larger than 1/4 of the whole breast
• •tumor bed unable to recognize on CT
• •prior invasive malignant tumor history
• •prior radiation to thoracic
• •connective tissue disease, such as active systemic lupus erythematosus and scleroderma, etc.
• •severe, active co-morbidity, defined as follows:
• •* unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
• •* severe, acute bacterial or fungal infection within the last 2 weeks
• •* chronic obstructive pulmonary disease exacerbation or other respiratory illness within 30 days
• •pregnant women