Post Mastectomy Hypofractionated Radiotherapy in High Risk Breast Cancer

Inclusion Criteria

• •Ipsilateral clinically diagnosed and histologically confirmed invasive breast cancer
• •Undergone total mastectomy and axillary dissection T 3-4 and/or 4 or more positive axillary lymph nodes.
• •Fit for chemotherapy ( if indicated) , endocrine therapy (if indicated), and postoperative irradiation.
• •Written informed concent.
• •C T3-4 , or C N2, or pathological positive axillary lymph nodes during mastectomy for patients who had received neoadjuvant chemotherapy or hormone therapy.
• •No supraclavicular or internal mammary nodes metastases.
• •No distant metastases .Enrollment date no more than 8 months after surgery or no more than 2 months after chemotherapy for patients who did't receive neoadjuvant therapy.
• •Enrollment date no more than 2 months after surgery for patients who had received neoadjuvant systemic therapy and did't need adjuvant chemotherapy.