Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Central Hospital, Nancy, France
Age
18–74
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
giving their informed consent
having a supratentorial malignant glioma, either grade 4 of St. Anne/Mayo grading, or glioblastoma multiforme according to WHO classification
having an inoperable brain tumor (diagnosed by stereotactic biopsy)
having a general status, evaluated by Karnofsky scale, \>60
having a life expectancy \>3 months
not having previously had a brain irradiation and/or adjuvant or neo-adjuvant chemotherapy
potentially having another cancer, if histology and clinical history are available for comparison
being able to take oral tablets
no HIV disease
satisfactory hematology, hepatic and renal functions: polymorphonuclear neutrophils \>1500/mm3, platelets \>100000/mm3, Hb \>8g/dl, creatinemia ≤1.5 times upper normal value, total bilirubin \<1.5 times upper normal value, ASAT and ALAT \<3 times upper normal value
for women of childbearing potential, a contraception is given
You may not be if
having an under tentorial malignant glioma (brain stem and/or cerebellum), grade 4 of St. Anne/Mayo grading
having a Karnofsky score \<60
having a life expectancy \<3 months
having had a brain irradiation or an adjuvant or neoadjuvant chemotherapy
refusing any additional therapy
having a non-malignant but serious systemic disease or uncontrolled active infection
