Depletion of Myeloid Derived Suppressor Cells to Enhance Anti PD-1 Therapy

Primary Objective • The primary objective of this proposal is to evaluate gemcitabine as a method of MDSC depletion. Secondary Objectives * Evaluate whether these measures result in enhanced T-cell activity and/or NK cell function and number. * Determine the tolerability and clinical activity (including response rate and survival) of this approach. * Correlate MDSC number with tumor PD-L1 expression