Contraceptive/HIV Affecting Risk in Adolescents

Exclusion Criteria

• •1. Use of any other hormonal contraception other than ENG-I or LNG-IUS
• •2. Use of a diaphragm or spermicide for contraception
• •3. Pregnant or pregnancy within 90 days
• •4. Currently breastfeeding
• •5. Currently menstruating/bleeding (at time of specimen collection) Note: participant can return after cessation of bleeding for specimen collection
• •6. Past participation in more than one study involving cervical biopsies per participant report
• •7. Cervical biopsies within one month of specimen collection visit
• •8. Abnormal vaginal discharge or other genital tract symptoms at the time of specimen collection
• •9. Pelvic findings on the day of specimen collection consistent with cervicitis (i.e. MPC, erythema, edema) or anatomy making cervical biopsies difficult
• •10. Menopausal
• •11. Hysterectomy
• •12. History of malignancy of the genital tract (including cervix, uterus, vagina, and vulva)
• •13. History of immunosuppression (including HIV infection, diabetes, and chronic steroid use)
• •14. Known history of a platelet/bleeding/clotting disorder
• •15. Use of a systemic or vaginal antimicrobial agent within 7 days of specimen collection
• •16. Use of any vaginal product (i.e. douching, spermicide, lubricant) or device within 7 days of specimen collection Note: tampon use is acceptable
• •17. Any other condition that in the opinion of the Study Investigator would preclude provision of informed consent or make study participation unsafe, complicate the interpretation of study outcome data, or otherwise interfere with achieving the study objectives.