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Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders | Clinical Trials | Clareo Health

COMPLETEDNA

Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders

NCT03299062•University of Arkansas

Summary

Degenerative dementias including Alzheimer's Disease (AD), Parkinson's Disease with Dementia (PDD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementias (FTLD), Corticobasal Degeneration (CBD) and Progressive Supranuclear Palsy (PSP) constitute a significant, and growing burden with an estimated cost to the US healthcare system for 2016 of $236 Billion (1). Definitive diagnosis of these dementias is based on pathological criterion upon autopsy, which presents a significant challenge to establish diagnosis in living patients. Although clinical diagnostic criteria have been developed for several of these disorders, including for Alzheimer's Disease (AD) by the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimers Disease and Related Disorders Association (NINCDS-ADRDA) , Parkinson's Disease (PD) by the United Kingdom Parkinson Disease Brain Bank Diagnostic Criteria (UKPDBB) diagnostic criteria for Parkinson Disease(4) and others, the currently available tests, including the use of imaging markers and Cerebrospinal Fluid (CSF) biological markers do not provide a definite diagnosis since this requires the observation of characteristic neuropathological changes in specific regions of the brain.

Eligibility

Age

19 - 89 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Diagnosed with idiopathic Parkinson's disease, progressive supranuclear palsy, Alzheimer's disease or Mild Cognitive Impairment based on consensus criteria, or suspicion of presbylarynx based on clinical evaluation.
•Require evaluation of voice dysfunction by an ENT doctor given symptoms of impaired voice volume or quality
•Age ≥ 18 years-old to ≤ 90-years old.
•Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria

•Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
•Active nose bleeds, or abnormal anatomy of the nose that prevent safe nasal swabs, or active oropharyngeal disease that prevents laryngoscopy or voice assessments.

Locations (1)

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Key Dates

Start Date

November 14, 2017

Primary Completion Date

December 21, 2021

Completion Date

December 21, 2021

Last Updated

November 25, 2022

Enrollment

ACTUAL participants

Conditions

Alzheimer DiseaseNeurodegenerative Diseases

Interventions

Cytology and Immunohistochemistry

DIAGNOSTIC_TEST

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RECRUITINGNA

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 25, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders

Inclusion Criteria

Exclusion Criteria

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