Loading clinical trials...

Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide | Clinical Trials | Clareo Health

UNKNOWNPHASE3

Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide

Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide: a Randomized Clinical Trial

NCT03298802•The University of Texas Medical Branch, Galveston

View on ClinicalTrials.gov

Summary

Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension.

Detailed Description

To evaluate effectiveness of hydrochlorothiazide prophylaxis on prophylaxis, prevention and relapse of preeclampsia or gestational hypertension on readmission rates, need for additional antihypertensive therapy and number of triage visits.

Eligibility

Age

18 - 50 years

Sex

FEMALE

Healthy Volunteers

Inclusion Criteria

•Maternal age ≥ 18 years and \<50 years.
•Diagnosis of gestational hypertension\* or preeclampsia\^ at any time during pregnancy, labor or postpartum.
•* defined as isolated systolic BP of 140 mm Hg or greater, a diastolic BP of 90 mm Hg or greater, or both) or \^ defines as new-onset hypertension plus new-onset proteinuria, or in the absence of proteinuria, preeclampsia is diagnosed as hypertension in association with thrombocytopenia (platelet count less than 100,000/microliter), impaired liver function (elevated blood levels of liver transaminases to twice the normal concentration), the new development of renal insufficiency (elevated serum creatinine greater than 1.1 mg/dL or a doubling of serum creatinine in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.)

Exclusion Criteria

•Subject requiring antihypertensive therapy at time of screening.
•Planned discharge with oral anti-hypertensive medication.
•Contraindication to hydrochlorothiazide (advanced renal failure or anuria, hypersensitivity to sulfonamides).
•Subject not able to follow up postpartum.
•Lactose intolerance.
•Pre-gestational diabetes.

Locations (2)

St. David's North Austin Medical Center

Austin, Texas, United States

University of Texas Medical Branch

Galveston, Texas, United States

Key Dates

Start Date

November 21, 2017

Primary Completion Date

August 30, 2024

Completion Date

August 30, 2024

Last Updated

December 5, 2023

Enrollment

612

ESTIMATED participants

Conditions

Pre-EclampsiaGestational HypertensionSuperimposed Pre-EclampsiaHypertension, Pregnancy-InducedPostpartum Pregnancy-Induced HypertensionPostpartum Preeclampsia

Interventions

Hydrochlorothiazide 50mg Tablet

DRUG

Placebo Tablet

DRUG

Contacts

Megan C Shepherd, M.D.

CONTACT

409-772-0312 mcshephe@UTMB.EDU

Ashley Salazar, RN

CONTACT

409-772-0312 assalaza@utmb.edu

APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia

NCT06408181

Pre-EclampsiaPregnancy Loss

View study

RECRUITINGPHASE4

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

NCT06468202

Hypertensive Disorders of PregnancyPreeclampsia+1 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 5, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide

Inclusion Criteria

Exclusion Criteria

APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History

Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

AtorvaStatin Postpartum and Reduction of Cardiovascular risK

Vascular Biomarkers Predictive of the Progression From Hypertensive Disorders in Pregnancy to Preeclampsia in Pregnant Women