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The Gut Microbiota in Conventional and Serrated Precursors of Colorectal Cancer
Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples. Investigators compared gut microbiota diversity, overall composition, and normalized taxon abundance among these groups.
Colorectal cancer is a heterogeneous disease arising from at least two precursors-the conventional adenoma (CA) and the serrated polyp. A relationship between the human gut microbiota and colorectal cancer has been shown; however, its relationship to the different early precursors of colorectal cancer is understudied. This study tested, for the first time, the relationship of the gut microbiota to specific colorectal polyp types.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
New York University School of Medicine
New York, New York, United States
Start Date
November 23, 2011
Primary Completion Date
April 25, 2015
Completion Date
April 25, 2015
Last Updated
September 29, 2017
540
ACTUAL participants
Mobio PowerSoil DNA Isolation Kit
DIAGNOSTIC_TEST
Lead Sponsor
NYU Langone Health
NCT04739722
NCT06515977
Data Source & Attribution
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