A Study of OMP-336B11 in Subjects With Locally Advanced or Metastatic Tumors

Inclusion Criteria

• •Locally advanced or metastatic solid tumors that have exhausted standard of care therapy
• •Measurable disease per response evaluation criteria in solid tumors (RECIST) v1.1
• •Age \>21 years
• •Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• •Adequate organ and marrow function
• •For women of childbearing potential and men with partners of childbearing potential, agreement (by patient and/or partner) to use two effective forms of contraception from study entry through at least 6 months after the termination visit.
• •Ability to understand and the willingness to sign a written informed consent document